Duration of Antibiotic Treatment in Community-Acquired Pneumonia
This noninferiority trial compares the effects of IDSA/ATS guideline–recommended vs conventional antibiotic treatment duration on symptom and clinical resolution in hospitalized patients with...
View ArticleAntibiotics in Hospitalized Patients With Asthma Exacerbations
This study uses medical record data from Premier Alliance to describe the receipt, type, and timing of antibiotic therapy in patients with asthma in 2013 and 2014.
View ArticleThe New Antibiotic Mantra—“Shorter Is Better”
In ad 321, Roman Emperor Constantine the Great codified that there would be 7 days in a week. Even in the modern era of evidence-based-medicine, this 1695-year-old decree remains a primary reference...
View ArticleAssociation of Sodium Selenite and Procalcitonin-Guided Therapy With Mortality
This randomized clinical trial evaluates the use of high-dose sodium selenite, with or without use of a procalcitonin algorithm to guide therapy, and its association with mortality in patients with...
View ArticleAzithromycin for Acute Exacerbations of Asthma
This randomized clinical trial examines whether azithromycin added to standard care for asthma attacks in adults results in clinical benefit.
View ArticleNational Trends in Inpatient Antibiotic Use Among US Hospitals
This analysis uses proprietary administrative data to estimate patterns of inpatient antibiotic usage in the United States from January 1, 2006, to December 31, 2012.
View ArticleTipping the Balance Towards Fewer Antibiotics
News of patients with broadly resistant “superbugs” have recently raised public awareness of the risks of antibiotic overuse. But unnecessary antibiotic use is not a new problem; it has been a public...
View ArticleAZALEA Trial Highlights Antibiotic Overuse in Acute Asthma Attacks
Asthma affects more than 300 million people worldwide, causing variable symptoms of cough, chest tightness, and exertional or nocturnal dyspnea due to chronic inflammation of the lower airways and...
View ArticleReceipt of Antibiotics by Prior Bed Occupants and Clostridium difficile Risk
This cohort study reports on the association of receipt of antibiotics by prior hospital bed occupants with increased risk for Clostridium difficile infection in patients subsequently occupying the...
View ArticleAntibiotic Treatment for Chronic Lyme Disease
This Teachable Moment describes the case of a woman who developed DRESS syndrome after unnecessary treatment for “chronic Lyme disease.”
View ArticleInappropriate Antibiotic Selection Among US Ambulatory Care Visits
This study measures the frequency with which first-line antibiotics are prescribed for otitis media, sinusitis, and pharyngitis.
View ArticleNational Trends in Inpatient Antibiotic Use Among US Hospitals
This analysis uses proprietary administrative data to estimate patterns of inpatient antibiotic usage in the United States from January 1, 2006, to December 31, 2012.
View ArticleTipping the Balance Towards Fewer Antibiotics
News of patients with broadly resistant “superbugs” have recently raised public awareness of the risks of antibiotic overuse. But unnecessary antibiotic use is not a new problem; it has been a public...
View ArticleAZALEA Trial Highlights Antibiotic Overuse in Acute Asthma Attacks
Asthma affects more than 300 million people worldwide, causing variable symptoms of cough, chest tightness, and exertional or nocturnal dyspnea due to chronic inflammation of the lower airways and...
View ArticleAntibiotic Treatment for Chronic Lyme Disease
This Teachable Moment describes the case of a woman who developed DRESS syndrome after unnecessary treatment for “chronic Lyme disease.”
View ArticleInappropriate Antibiotic Selection Among US Ambulatory Care Visits
This study measures the frequency with which first-line antibiotics are prescribed for otitis media, sinusitis, and pharyngitis.
View ArticleAssociation of Physician Feedback With Antibiotic Use in Primary Care
This randomized trial examines the effect of giving quarterly antibiotic prescription feedback to primary care physicians in Switzerland over the course of 2 years.
View ArticleClarifying a “Penicillin” Allergy
This Teachable Moment highlights the importance of a thorough evaluation of a self-reported reaction to penicillin to prevent unnecessary labeling of penicillin allergy.
View ArticleAntimicrobial Stewardship and Appropriate Antimicrobial Prescribing in Hospitals
This study examines whether an antimicrobial stewardship approach grounded in behavioral theory and focusing on preserving prescriber autonomy and participation is associated with appropriateness of...
View ArticleAdverse Events and Antibiotic Use in Hospitalized Patients
This cohort study describes the incidence of antibiotic-associated adverse drug events for adult inpatients receiving systemic antibiotic therapy.
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